Sunday, 4 April 2010

RIT: an exciting new treatment for acute myeloid leukaemia.

Acute myeloid leukaemia (AML) is a blood-borne cancer that has responded extremely well to radioimmunotherapy in trials. Most studies targeted the protein CD33 which is found in high numbers on the surface of most AML cells. The antibody M195 recognises and binds to CD33. In a research study, M195 was joined to a radioactive agent and used to treat AML patients. Within one hour of administration, the radioactively labelled antibodies had found and bound to the leukaemia cells, showing an extremely powerful anti-cancer effect with the death of more than 99% of the leukaemia cells.
Usually, an allogeneic bone marrow transplant (BMT), involving bone marrow cells being taken from a donor and transplanted into the patient, is the only chance for a cure for patients with returning or unresponsive (to chemotherapy) leukaemias. Although, even this treatment results in only a 20-25% cure rate. Scientists decided to use radioactive antibodies in an attempt to increase the number of leukaemia patients being cured. Experiments including radioactive antibodies into the normal treatment routine with the usual cancer therapies; chemotherapy drugs and/or radiation treatment of the entire body. The reason cancer treatments are used before a bone marrow transplant is to kill as many of the cancerous blood cells as possible before the new, healthy blood cells are transplanted into the patient, therefore lowering the risk that the cancer will return. The outstanding results showed a cure rate of 93% following the bone marrow transplant.

For further information:
http://www.cancer.gov/cancertopics/factsheet/Therapy/bone-marrow-transplant

3 comments:

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